Most mild cases of sinusitis resolve on their own within a week or two with some self-care practices. Over-the-counter medications like pain relievers (paracetamol or ibuprofen) to manage discomfort, decongestants to open up blocked nasal passages, and nasal saline irrigation to clear mucus buildup can provide significant relief. However, if bacterial infection is suspected, antibiotics prescribed by your pharmacist or doctor may be necessary for effective treatment.