Wegovy injections have quickly become one of the most talked-about treatments for weight loss in the UK. In the SELECT trial (Semaglutide Effects on Cardiovascular Outcomes in People with Overweight or Obesity), involving over 17,600 adults with overweight or obesity and established cardiovascular disease but no diabetes, Wegovy reduced the risk of major adverse cardiovascular events (MACE) by 20% compared to placebo over nearly 40 months.
With evidence like that, many people are asking not just how much weight they can lose but whether Wegovy is safe to use long-term. This guide explores what the research says, what risks there may be, and what to know if you are considering starting or continuing treatment.
What exactly are Wegovy injections?
Wegovy contains semaglutide, a medicine that works by mimicking a natural hormone called GLP-1. This hormone plays an important role in appetite control and digestion. By slowing down how quickly food leaves the stomach and helping you feel fuller, Wegovy can make it easier to manage portion sizes and stick to a healthier diet.
Why are they used for weight loss?
Research shows that people taking Wegovy alongside lifestyle changes can lose on average up to 15% of their body weight over a 68-week period. This makes it one of the most effective medical treatments for weight loss currently available.
Who can use Wegovy?
Wegovy is generally prescribed for adults who are obese or for those who are overweight with related health concerns such as high blood pressure, type 2 diabetes or sleep apnoea. Suitability is always assessed on an individual basis.
Is Wegovy safe for long-term use?
The safety of Wegovy has been studied in large clinical trials lasting over a year, and the results are reassuring for most patients.
Common side effects include:
- Nausea
- Diarrhoea or constipation
- Stomach discomfort
- Fatigue
These often reduce over time as the body adjusts.
Are there serious risks?
Although uncommon, some people may experience:
- Inflammation of the pancreas (pancreatitis)
- Gallbladder problems such as gallstones
- Kidney issues if dehydration occurs due to severe vomiting
Because of these potential risks, regular monitoring is recommended. Our pharmacists always review your health history before starting or continuing treatment to make sure it is safe for you.
Does safety change over time?
Current evidence suggests that using Wegovy long-term does not necessarily make side effects worse, but it does highlight the need for ongoing check-ups. If side effects become troublesome or new health issues arise, your treatment plan may need to be adjusted.
How long can you take Wegovy safely?
There is no strict time limit on how long you can take Wegovy. Many people continue for several years, as long as the treatment is working well and side effects remain manageable.
Factors that influence how long you stay on Wegovy include:
- How effective it is for your weight loss goals
- Whether side effects are tolerable
- Any changes to your overall health
- Guidance from your pharmacist or prescriber
What happens if you stop taking it?
Once you stop Wegovy, your appetite and digestion usually return to how they were before treatment. This can often lead to regaining weight unless healthy eating and activity levels are maintained. That is why lifestyle changes are an essential part of long-term weight management, whether or not you stay on the injection.
What do experts recommend for long-term safety?
Leading health bodies such as the NHS recommend that Wegovy should always be used as part of a wider weight management plan rather than on its own. The safest way to use Wegovy in the long term is with:
- Regular reviews with a qualified pharmacist or prescriber
- A balanced diet supported by a nutrition plan
- Increased daily activity or exercise where possible
- Awareness of possible side effects and when to seek help
By combining medical treatment with lifestyle support, you are more likely to see lasting benefits without unnecessary risks.
Should you consider Wegovy for your weight journey?
Wegovy injections can be a safe and effective choice for many people when used long-term under professional guidance. The key is regular monitoring, realistic expectations, and a commitment to lifestyle changes alongside the medicine.
Book your appointment with our experts at Touchwood Pharmacy to explore whether Wegovy injections are the right long-term option for your weight management journey.
FAQs on Long-Term Safety of Wegovy Injections
Can you take Wegovy injections for years without problems?
Yes, many people continue taking Wegovy for several years if it remains effective and safe for them. Long-term use is possible with regular reviews to ensure side effects and overall health remain under control.
Does the risk of side effects increase the longer you take Wegovy?
Current studies show that most side effects, such as nausea or constipation, tend to improve with time. Serious issues like pancreatitis or gallbladder problems remain rare, even with long-term use, but ongoing monitoring is important.
What happens to your weight if you stop Wegovy after long-term use?
Stopping Wegovy often leads to a return of appetite and digestive patterns, which can cause weight regain. This is why diet and exercise habits are essential for maintaining weight loss even after discontinuing treatment.
Is Wegovy safe in the long term for people with conditions like diabetes or high blood pressure?
Yes, Wegovy can be used in people with conditions such as type 2 diabetes or high blood pressure, but safety depends on individual health status. Our pharmacists carefully assess your medical history to ensure it is suitable for you.
How often should you be monitored if using Wegovy for the long term?
Regular check-ups are recommended, usually every few months, to review your progress, side effects, and any changes in health. This helps make sure the benefits of Wegovy continue to outweigh any risks.
Can everyone stay on Wegovy long-term, or are some people advised to stop?
Not everyone can continue indefinitely. Some people may stop due to side effects, new health conditions, or reduced effectiveness. In such cases, alternative weight management strategies can be explored with professional guidance.
